Effect of salt on the formation of salt-bridges in β-hairpin peptides.

نویسندگان

  • Shahar Sukenik
  • Yoav Boyarski
  • Daniel Harries
چکیده

Salt-bridges ubiquitously form between oppositely charged moieties in proteins. Here we quantify changes in population of salt-bridged β-hairpin peptides due to added salt, and determine the thermodynamic driving forces and cooperativity of salt-bridge formation under these conditions. We find only a fraction of salt-bridged folded conformations at physiologically relevant salt concentrations.

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عنوان ژورنال:
  • Chemical communications

دوره 50 60  شماره 

صفحات  -

تاریخ انتشار 2014